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KMID : 0352519840210010265
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Korea Univercity Medical Journal
1984 Volume.21 No. 1 p.265 ~ p.270
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A Study of Phytohemagglutinin Binding on Gastric Carcunima Cells
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羅泳燦/Rah, Young-Chan
廉範愚/金世民/Yoem, Bum-Woo/Kim, Sae-Min
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Abstract
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To evaluate the binding reactions of various phytohemagglutinins (PHAs) on the gastric carcinoma cells, the author had undertaken an experiment using purified PHAs, such as Concanavalin A (Con-A) , wheat germ agglutinin (WGA), soybean agglutinin (SBA), Dolichos biflorus agglutinin (DBA), Ulex europaeus agglutinin I (UEA I), peanut agglutinin (PNA), Ricinus communis agglutinin I (RCA 1), and Pinellia ternata agglutinin (PTA). The tissue samples used were gastric tissue from subtotal gastrectomy or fiberoptic biopsy, diagnosed by pathologists as well differentiated adenocarcinoma and poorly differentiated adenocarcinoma signet-ring cell type adenocarcinoma, and dysplasia.
The results obtained are as follows;
1. On the well-differentiated adenocarcinoma, all the PHAs except UEA I showed cytoplasmic granular reactions of the tumor cells and linear reactions along the intraluminal borders of the tumor glands.
2. On the poorly differentiated adenocarcinoma, RCA I and UEA I showed cytoplasmic reactions, and other PHAs showed variable reactions from positive to focal positive.
3. In signet-ring cell carcinoma, PNA, SBA, RCA I and UEA I showed weak reactions in the cytoplasm.
4. On the dysplastic cells, Con-A, WGA, PNA, RCA I and PTA showed cytoplasmic reactions and SBA, UEA I and DBA showed no reaction.
With the above results, the binding of PHAs on the tumor cells of the stomach revealed variable patterns, depending on the degree of differentiation and the kinds of PHAs used.
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KEYWORD
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